Полный просмотр
- Любой режим просмотра
- Предварительный и полный просмотр
- Полный просмотр
Книги
Ion channels coordinate the movement of ions across biological membranes in response to a diversity of cellular signals to regulate most if not all aspects of physiology.
... Ca2+ response. 2. Results 2.1. Stromal Interaction Molecule 1 (STIM1) Knockout Represses Store-Operated Ca2+ Entry (SOCE) in Mouse Embryonic Fibroblasts (MEF) Cells In order to investigate the effect of STIM1 on SOCE, wild-type (MEF-WT) ...
... Ca2+ [reviewed by Richter and Kass (8)]. Mitochondria take up and release Ca2+ by separate routes. As a consequence, Ca2* is cycled across their inner membranes (7). Mitochondria are of central importance for physiologic Ca2+ handling ...
... Ca2+ during hibernation may result from increased cytoplasmic Ca2+ or SR Ca2+ leakage. Further studies were subsequently carried out to explore the mechanisms involved in intracellular Ca2+ fluctuations during hibernation. 3.5. Relative ...
... Ca2+ uptake [166,167]. They act as mild mitochondrial uncouplers without altering cytosolic Ca2+ levels. This mild mitochondrial depolarization was able to prevent NMDA- and Aβ-induced mitochondrial Ca2+ uptake and cell death ...
... Ca2+ homeostasis is critical for normal cellular function, particularly for cardiomyocytes, and may be dysregulated in early atrial myopathy. Store-operated Ca2+ entry (SOCE) is recognized to coexist with voltage-gated Ca2+ channels ...
... Ca2+ release in the process of FSE-mediated GLUT4 translocation and the increase in intracellular Ca2+ levels. To support this hypothesis, we used 100 μM 2-APB to block IP3R-regulated intracellular Ca2+ release. We found that 2-APB ...
... Ca2+] ([Ca2+] i ) (see description in the text). In salivary gland acinar cells, IP3 -mediated Ca2+ release occurs primarily via IP3R2 and -3 [4,5]. Importantly, the resulting decrease in ER-[Ca2+] triggers the activation of Ca2+ influx ...
... Ca2+ signals propagate inside the cells. To this end, Ca2+ release from the endoplasmic reticulum into the cytosol through IP3 Rs are Ca2+ channels whose open probability depends on the cytosolic Ca2+ concentration. Therefore, the ...
... Ca2+. A relationship between Ca2+ oscillations and PD neuronal loss was initially proposed by experiments showing a decline in the number of calbindin (a Ca2+ binding protein), positive neurons in PD patients [46,47]. These slow Ca2+ ...