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Simultaneous detection of membrane contact dynamics and associated Ca
Nature
Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites...
3 недели назад
Dysfunction of Mitochondrial Ca2+ Regulatory Machineries in Brain Aging and Neurodegenerative Diseases
Frontiers
Here, we discuss current research into mitochondrial Ca 2+ regulatory machineries and how mitochondrial Ca 2+ dysregulation contributes to brain aging and...
5 месяцев назад
Bypassing Ca2+ Influx for Antimetastasis Photodynamic Therapy via Robust Nucleus-Targeted Near-Infrared Cyanines
ACS Publications
Hypoxia-induced tumor metastasis severely hinders the efficacy of photodynamic therapy (PDT) in cancer treatment.
1 неделю назад
channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
Nature
Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and,...
2 месяца назад
The potential roles of T-type Ca2+ channels in motor coordination
Frontiers
T-type Ca2+ channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits.
4 месяца назад
Overload Combined with Chemodynamic Therapy to Enhance Cancer Immunotherapy
ACS Publications
We engineered a nanoplatform based on CaO 2 nanoparticles (NPs) capable of encapsulating curcumin (CUR) and self-supplying H 2 O 2 for synergistic CDT-...
1 месяц назад
Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis | Scientific Reports
Nature
Calcium oscillations in primary neuronal cultures and iPSCs have been employed to investigate arrhythmogenicity and epileptogenicity in drug...
3 недели назад
Waves of Inner Supporting Cells in the Developing Mouse Cochlea
Frontiers
We provide evidence that IHCs autonomously generate single fCaTs and minibursts whereas bursts synchronized between neighboring IHCs were mostly triggered by...
5 месяцев назад
–CPK signalling controls root cap cycle plasticity and stress adaptation
Nature
Abscisic acid (ABA) regulates plant stress adaptation, growth and reproduction. Despite extensive ABA–Ca2+ signalling links,...
2 недели назад
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation
Frontiers
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation ... Introduction: The mitochondrial...
5 месяцев назад