This title was first published in 1986. It comprises contemporary knowledge of the calcium pump of plasma membranes and associated fields of research.
This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years.
This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a ...
... Ca2+ channel has been observed (Stanley, 1993), in most synap- ses exocytosis appears to normally be due to Ca2+ enter- ing through clusters of Ca2+ channels in active zones and contributing to local high [Ca2+] at docked vesicles: 1 ...
... Ca2+ handling plays an important role in the pathogenesis of HF, and this kind of alteration in myocytes is a primary defect causing contractile dysfunction in HF (Yano et al. 2005). Modifications in the expression and/or activity of Ca2+ ...
... Ca2+. However, aside from this special case, Ca2+ influx through AMPA receptors does not seem to play a major role in astrocyte Ca2+ signaling because in most brain regions astrocytes express AMPA receptors that contain the GluR2 sub ...
... Ca2+ release from the endoplasmic reticulum (ER). The positive feedback (+ve) of Ca2+ on the IP3 receptor (IP3 R. CICR and R limit initiates the Ca2+ Ca2+-induced increase. Some Ca2+ release (CICR) through the IP3 The elevated Ca2+ has ...
... Ca2+ mobilization and Ca2+ entry mechanisms coupled to the α mesenteric 1 -adrenoceptor arteries in were resistance kept in a arteries, nominally endothelium-denuded Ca2+-free medium, stimulated with PE and further activated with ...
... Ca2+] i may be regulated independently, Ca2+ waves generated in the cytoplasm can spread into the nucleo- plasm of several cell types. Furthermore, cytoplasmic Ca2+puffs can cause transient increase in nucleoplas- mic [Ca2+]. In HeLa ...
... Ca2+ pool contributes to whole-cell intracellular Ca2+ transients in human iPSC-CMs (Itzhaki et al., 2011). To maintain sustainable Ca2+ cycling, released Ca2+ must be removed from the cytosol. In adult human CMs, 70% of cytosolic ...