... Ca2+ antagonists are not a uniform chemical substance class, but are divided into several main groups. The phenylalkylamines, with the prototype verapamil, the dihydropyridines, with the prototype nifedipine, and the benzothiazepine ...

... Ca2+ current in response to Ca mobilizing agonists [40]. It is also reported that the intracellular ATP dose-dependently enhances the L-type Ca2"1" current without altering its voltage- dependent features [41,42]. p-agonists increase ...

... Ca2+ channels over L-type Ca2+ channels is probably responsible for many of its unique properties. It does not have the negative inotropic effects associated with some Ca2+ antagonists [50]. Its efficacy and tolerability in the ...

... Ca2+ channel blockers, when combined with CQ, fail to increase CQ susceptibility in CQ-sensitive strains of P. falciparum [12, 16]. The reversal activity of Ca2+ antagonists has opened a debate on the role of Ca2+ transport systems in ...

... Ca2+]i in VSMC isolated from rat tail arteries [94]. Such a change in [Ca2+]i correlated well with the stimulatory effect of 1.25D on L-type calcium channel activity in the same type of VSMC. Whether 1.25D directly acts on the channel ...

... Ca2+ compete with H+ for common sites of binding in cytoplasm. According to the data presented elsewhere [12], Ca2+ efflux through membrane of rat thymocytes may be activated by a direct increase in pH, for instance by the external ...

... Ca2+ efflux from the ER may induce apoptosis in a variety of ways, which may include events such as reactive oxygen species (ROIs, "free radicals"), excess mitochondrial Ca2+ uptake, or activation of gene transcription [175]. Activation ...

... Ca2+ from intracellular stores. A pertussis toxin-sensitive increase in cytosolic calcium on 1L-8 stimulation has been reported in various cell lines [9, 41. 89]. Activation of PKC has been proposed in the lL-8-mediated signalling ...

... Ca2+ reabsorption in the distal tubules. Since Ca2+ and phosphate have a solubility product relationship (i.e., the product of the concentration of free ions is constant) a drop in blood phosphate requires an increase in Ca2+ released ...

... Ca2+ at 37 °C for 30 ffiin. The volumes of RBC were registered using a method of resistance pulse spec Iroscopy during pumping of the cell suspension with the rate of 1 .8 filIsec through a microhole with the diameter of 50 /<m and ...