Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and, thus,...
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Here, we establish Ca 2+ signals between the two sources as fundamental building blocks that couple local release to global changes in Ca 2+.
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We reveal a hierarchy of cells, each with a different level of influence over islet-wide Ca 2+ dynamics. First-responder β cells lie at the top of the...
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Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases.
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We conclude that Copine-6 is a postsynaptic Ca 2+ sensor that mediates AMPA receptor exocytosis during synaptic potentiation.
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Here, we develop photocatalyst-based metal-organic frameworks (DCSA-MOFs) to modulate Ca 2+ responses in cells, multicellular spheroids, and organs.
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We propose that neuron–OPC synapses are dynamically assembled and can predetermine myelination patterns through Ca 2+ signaling.
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Here we identify bona fide cell surface hypo-osmosensors in Arabidopsis and find that pollen Ca 2+ spiking is controlled directly by water through these hypo-...
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We find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow.
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Action potentials trigger neurotransmitter release at the presynaptic active zone with spatiotemporal precision. This is supported by protein machinery that...
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