Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and,...
2 ìåñÿöà íàçàä

Dysfunction of Mitochondrial Ca²⁺ Regulatory Machineries in Brain Aging and Neurodegenerative Diseases ... Calcium ions (Ca²⁺) play critical roles in neuronal...
5 ìåñÿöåâ íàçàä

The Ca²⁺ from CaO2 NPs and the elevated level of endogenous Ca²⁺ induced by CUR trigger Ca²⁺ overload and mediate apoptosis in tumor cells. The...
1 ìåñÿö íàçàä

IP3 receptor (IP3R)-mediated Ca2+ transfer at the mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) drives mitochondrial Ca2+...
2 ìåñÿöà íàçàä

The mitochondrial Ca²⁺ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation ... Introduction: The mitochondrial...
5 ìåñÿöåâ íàçàä

Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites...
1 ìåñÿö íàçàä

The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca²⁺.
3 ìåñÿöà íàçàä

Action potentials trigger neurotransmitter release at the presynaptic active zone with spatiotemporal precision.
3 ìåñÿöà íàçàä

Mitochondrial Ca²⁺ accumulation stimulates aerobic metabolism by inducing the activity of three TCA cycle dehydrogenases. In detail, matrix Ca²⁺ indirectly...
10 ìåñÿöåâ íàçàä

Calcium oscillations in primary neuronal cultures and iPSCs have been employed to investigate arrhythmogenicity and epileptogenicity in drug...
1 ìåñÿö íàçàä