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channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
Nature
Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic resistance and trapping of immune cells and,...
1 месяц назад
Nernst-Planck-Gaussian finite element modelling of Ca2+ electrodiffusion in amphibian striated muscle transverse tubular-sarcoplasmic reticular triadic junctional domains
Frontiers
Introduction. Intracellular Ca2+ signalling regulates membrane permeabilities, enzyme activity and gene transcription amongst other...
1 неделю назад
signaling for regulating cellular and animal behaviors via MOF-enabled H
Science | AAAS
Here, we develop photocatalyst-based metal-organic frameworks (DCSA-MOFs) to modulate Ca 2+ responses in cells, multicellular spheroids, and organs.
6 месяцев назад
Development of a Dual Reporter System to Simultaneously Visualize Ca2+ Signals and AMPK Activity
ACS Publications
We introduce a new separation of phases-based activity reporter of kinase (SPARK) for AMP-activated kinase (AMPK), named AMPK-SPARK, which reports the AMPK...
2 месяца назад
Contributes Superior Anti-Freezing Aqueous Electrolytes and Stabilizes the Zn anode
Wiley Online Library
The “super hydrous solvated” structure is proposed to solve the problem of low temperature poor performance and Zn anode instability for...
4 месяца назад
ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca
Nature
IP3 receptor (IP3R)-mediated Ca2+ transfer at the mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) drives mitochondrial Ca2+...
3 недели назад
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation
Frontiers
The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation ... Introduction: The mitochondrial...
4 месяца назад
Osmosensor-mediated control of Ca2+ spiking in pollen germination
Nature
Here we identify bona fide cell surface hypo-osmosensors in Arabidopsis and find that pollen Ca 2+ spiking is controlled directly by water through these hypo-...
5 месяцев назад
The potential roles of T-type Ca2+ channels in motor coordination
Frontiers
T-type Ca2+ channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits.
3 месяца назад
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors
Nature
Our findings uncover the key steps of a previously unappreciated mechanism utilized by mammalian cells to finetune their calcium signaling regulation through...
1 месяц назад